Called Catedral de la Encarnación de María. It was founded together with the San Miguel de Tucumán city, on May 31, 1565. The current cathedral was blessed on February 19, 1856, after having moved the capital city from Ibatín´s field to current location. It is one of the most ancient cathedrals of Argentina, after that of Buenos Aires and that of Córdoba.
In the design we can find different styles, the Doric one was used in the low floor, the Ionic one in the intermediate floor and the Corinthian in the upper. In the high of the structure exhibits bulbous domes of oriental reminiscence. In the tower of the left side one finds a clock belonged to Cabildo de Tucumán, whereas the bells of the tower of the right date back of the times of construction of the temple. The pediment is decorated by a bas-relief whose subject matter symbolizes the Biblical passages of the Book of the Numbers, referred to the voyage of Moses in the desert, when this one rests in the shade of a cedar, while the Israelites carry a prodigious bunch of grapes.